This three-part episode follows a discussion of the current state of HCT by exploring its evolution over time. Fred Appelbaum, MD, of Fred Hutchinson Cancer Center, and Courtney Bellomo, MD, of New York Oncology Hematology lead the discussion. In Part I: Transplant Then and Now, they examine what HCT looked like when they first started practicing compared to what it is today, learning alongside E. Donnall Thomas, Nobel Prize winner in HCT. Major advances in HCT and access to care are explored. For more information, resources from the episode, or full bios of our guests, visit our Explore Cell Therapy site.